Comparison of Rapidly Proliferating, Multipotent Aortic Valve-Derived Stromal Cells and Valve Interstitial Cells in the Human Aortic Valve

Figure 4

Comparison of global gene expression profiles between VICs and VDSCs. (a) Box plot shows the distribution of gene expression levels in each sample, and the dispersion of the data distribution can be observed; adipose mesenchymal stem cells (AdMSCs) were used for the reference. (b) Heat map for the Pearson correlation coefficient of all gene expression levels between samples; the higher the correlation coefficient indicates, the more similar the gene expression level. (c) Heat map for the global gene expression with group clusters (). (d) Scatter plot of differentially expressed genes (DEGs) in VDSCs versus VICs (upregulation: 301 and downregulation: 1294); was accepted as positive DEGs. (e) GO enrichment of those selected DEGs including the biological process (red), cellular component (blue), and molecular function (yellow); broken line indicates value (-log10). (f) KEGG pathways enrichment bubble map; a larger value (-log10) indicates a higher degree of enrichment.

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