Oct4 Gene Expression in Primary Colorectal Cancer Promotes Liver Metastasis

Table 3

Results of univariate and multivariate analyses of liver metastasis-free survival.

Factors	Univariate analysis			Multivariate analysis
	HR	95% CI	value	HR	95% CI	value
Age (years) (<66/≥66)	1.008	0.484–2.112	0.983
Sex (male/female)	1.696	0.805–3.798	0.167
Preoperative CEA (≥5/<5)	1.277	0.526–2.732	0.526
Histological grade (other/Tub1–2)	2.573	0.613–7.309	0.170
Lymphatic invasion (present/absent)	2.085	0.959–5.012	0.064
Vascular invasion (present/absent)	1.587	0.657–4.714	0.324
TNM stage (3-4/1-2)	8.232	2.896–34.536	<0.001	7.789	2.737–32.700	<0.001
Oct4 expression (high/low)	2.866	1.319–6.888	0.007	2.613	1.201–6.284	0.015

Other: poorly differentiated, mucinous adenocarcinoma, or squamous cell carcinoma. Tub1: well-differentiated adenocarcinoma; Tub2: moderately differentiated adenocarcinoma.