Effects of Delta-Like Noncanonical Notch Ligand 1 Expression of Human Fetal Liver Hepatoblasts on Hematopoietic Progenitors

Figure 2

Gene expression of human fetal liver cells after DLK1 knockdown. Total human fetal liver cells were cultured for three (dark grey bars) or five (light grey bars) days with DLK1-targeting siRNA and analyzed for their expression of the hepatic, hematopoietic, endothelial, and cell cycle genes. Gene expression is given as percent of the respective control (100%) that received nontargeting control siRNA. Data are given as means from different deviation. , , and indicate statistically significant differences (, , and , respectively). Abbreviations: AFP: alpha-fetoprotein; CCNE1: cyclin E1; CD34: cluster of differentiation 34; DLK1: delta-like noncanonical Notch ligand 1; EPCAM: epithelial cell adhesion molecule, CD326; GYPA: glycophorin A, CD235a; KRT19: keratin 19, type 1, cytokeratin 19; MKI67: marker of proliferation Ki-67; PECAM1: platelet and endothelial cell adhesion molecule 1, CD31; PTPRC: protein tyrosine phosphatase, receptor type C, CD45; VWF: von Willebrand factor.