Mesenchymal Stem Cell Therapy Facilitates Donor Lung Preservation by Reducing Oxidative Damage during Ischemia
Lung functional data. (a) Pressure-volume curves in mechanically ventilated lungs. Curves were generated by using sequential pressure steps in which the tidal volume reached at each step was measured by the ventilator. Open symbols represent basal measurements, and closed symbols represent measurements obtained at the end of the perfusion. Graphs show a baseline vs. endpoint pressure-volume curve for a representative lung from vehicle and HUCPVC groups. The slope of the pressure-volume curve represents the lung compliance. (b) Individual changes in lung compliance for vehicle and HUCPVC groups. Lung compliance was determined at baseline (open symbols) and at the end of the perfusion (closed symbols) from pressure-volume curves data. vs. basal derived from paired test. (c) Lung compliance reduction expressed as percentage with respect to baseline. derived from unpaired test.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.