Human Amnion Epithelial Cell Therapy for Chronic Liver Disease

Figure 4

Functions of CD4⁺ T-cell subsets in liver fibrosis. The differentiation of naive CD4⁺ T cells into distinct functional subtypes is driven by factors produced by injured parenchymal cells and other inflammatory cells, namely, macrophages. Tregs suppress other T-cell subsets and limit the magnitude of inflammation and fibrosis during tissue repair.