Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy

Table 1

Literature summary of BM-MSC in the antifibrotic process.

Researcher	Fibrogenic signal pathway involved	Delivery method	Animal model	Heterogeneity
da Silva et al. [51]	Not mentioned	Abdominal vena cava	Rat UUO	Syngeneic
Asanuma et al. [52]	Not mentioned	Renal artery	Rat UUO	Xenogeneic (from human)
Wu et al. [53]	P38 and NF-κB	i.v.	Mouse BSA-induced proteinuria (CKD model)	Murine
Ninichuk et al. [55]	Not mentioned	Tail vein	COL4A3-deficient mouse (Alport disease model)	Murine
Lang and Dai [56]	TGF-β1/Smad3	i.p.	Rat STZ-induced diabetic nephropathy	Syngeneic
Matsui et al. [57]	JAK-STAT3	Renal artery	Rat UUO	Xenogeneic (from human)
Song et al. [45]	NF-κB and ERK	Tail vein	ADR-induced nephropathy mouse model	Xenogeneic (from human)
Wang et al. [61]	TGF-β1	i.v.	Mouse UUO	Xenogeneic (from human)

i.v.: intravenously; i.p.: intraperitoneally.