Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy

Table 2

Literature summary of UC- (WJ-) MSC in the antifibrotic process.

Researcher	Cell/substance transferred	Fibrogenic signal pathway involved	Delivery method	Animal model	Heterogeneity
Rodrigues et al. [47]	WJ-MSC	TGF-β1	i.p.	Rat IRI	Xenogeneic (from human)
Du et al. [70]	WJ-MSC	Akt and TGF-β1	Tail vein	Rat IRI	Xenogeneic (from human)
Fan et al. [69]	WJ-MSC	TGF-β	i.p.	Rat peritoneal dialysis- (PD-) elicited fibrosis model	Xenogeneic (from human)
Zhang et al. [62]	WJ-MSC MV	NOX 2	Caudal vein	Rat IRI	Xenogeneic (from human)
Wu et al. [78]	WJ-MSC MV	TGF-β1	i.v.	Rat DCD renal transplantation	Xenogeneic (from human)
Li et al. [73]	WJ-MSC	TGF-β	Tail vein	Adenine-induced CRF rat model	Xenogeneic (from human)
Huang et al. [79]	uUC-MSC	Not mentioned	Tail vein	Rat UUO	Xenogeneic (from human)
Liu et al. [80]	uUC-MSC CM	TGF-β1	Renal artery	Rat UUO	Xenogeneic (from human)
Liu et al. [48]	uUC-MSC CM	TLR4/NF-κB	Renal artery	Rat UUO	Xenogeneic (from human)
Park et al. [81]	uUC-MSC	Not mentioned	i.v.	Rat STZ-induced diabetic nephropathy	Xenogeneic (from human)
Zou et al. [76]	uUC-MSC EV	HIF-1α	Caudal vein	Rat IRI	Xenogeneic (from human)
Zhou et al. [85]	uUC-MSC exosome	p38MAPK and ERK 1/2	Renal capsule	Cisplatin-induced AKI rat model	Xenogeneic (from human)
Rota et al. [31]	uUC-MSC	Not mentioned	Tail vein	ADR-induced nephropathic athymic rat	Xenogeneic (from human)