Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy

Table 4

Registered clinical trials of MSCs in renal fibrosis and CKD (ClinicalTrial.gov, updated September 2018).

Registered no.	Status	Title	Population (age: year-old)	Phase	Source of MSCs	Location	Start date
NCT00659620	Unknown	Mesenchymal stem cell transplantation in the treatment of chronic allograft nephropathy	20 (18-60)	1 and 2	Bone marrow	Fuzhou, China	May 2008
NCT00733876	Completed	Allogeneic multipotent stromal cell treatment for acute kidney injury following cardiac surgery	15 (>18)	1	Bone marrow	Murray, Salt lake city, United States	August 2008
NCT00734396	Completed	Mesenchymal stem cells and subclinical rejection	15 (18-65)	1 and 2	Bone marrow	Leiden, Netherlands	February 2009
NCT01840540	Completed	MSC for occlusive disease of the kidney	6 (40-80)	1	Adipose	Rochester, United States	April 2013
NCT01967186	Unknown	Intraportal or intramuscular site for islets in simultaneous islet and kidney transplantation	36 (18-65)	Not applicable	Bone marrow	The Nordic network for clinical islet transplantation	April 2007
NCT02057965	Recruiting	Mesenchymal stromal cell therapy in renal recipients	70 (18-75)	2	Bone marrow	Leiden, Netherlands	March 2014
NCT02166489	Completed	Mesenchymal stem cell transplantation in patients with chronic renal failure due to polycystic kidney disease	6 (18-60)	1	Bone marrow	Tehran, Iran	March 2014
NCT02195323	Completed	Autologous bone marrow-derived mesenchymal stromal cells (BM-MSCs) in patients with chronic kidney disease (CKD)	7 (25-60)	1	Bone marrow	Tehran, Iran	April 2014
NCT02266394	Recruiting	Hypoxia and inflammatory injury in human renovascular hypertension	42 (40-80)	1	Adipose	Birmingham, Rochester, Jackson, United States	October 2014
NCT02387151	Active, not recruiting	Allogeneic mesenchymal stromal cell therapy in renal transplant recipients	10 (18-75)	1	Bone marrow	Leiden, Netherlands	March 2015
NCT02565459	Recruiting	MSC and kidney transplant tolerance (phase A)	22 (18-75)	1	Bone marrow	Bergamo, Italy	September 2015
NCT02966717	Active, not recruiting	Rituximab combined with MSCs in the treatment of PNS (3-4 stages of CKD)	116 (18-65)	2	Not mentioned	Guangzhou, China	August 2016
NCT03321942	Recruiting	Treatment of chronic renal failure with adipose tissue-derived mesenchymal stem cells	100 (18-75)	Not applicable	Adipose	Xuzhou, China	January 2017