Notch Inhibition Promotes Differentiation of Liver Progenitor Cells into Hepatocytes via <i>sox9b</i> Repression in Zebrafish

<div>Pharmacological Notch inhibition promotes differentiation of LPCs into hepatocytes. (a) Experimental scheme illustrating the periods of MTZ and LY411575 treatment and analysis stages (arrow). (b) Single-optical section images showing Hnf4a and <i>Tp1:</i>H2B-mCherry expression in regenerating livers at A33h and R6h. Arrows point to Hnf4a<sup>+</sup> BEC-derived cells; arrowheads point to Hnf4a<sup>-</sup> BEC-derived cells. (c) Quantification of the percentage of Hnf4a<sup>+</sup> cells among BEC-derived cells, as shown in (b). (d) qPCR data showing the relative expression levels of <i>fabp10a</i>, <i>bhmt</i>, <i>tfa</i>, and <i>sox9b</i> between DMSO- and LY411575-treated regenerating livers at R6h. 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Stem Cells International

fig1

Figure 1

Figure 1: Notch Inhibition Promotes Differentiation of Liver Progenitor Cells into Hepatocytes via <i>sox9b</i> Repression in Zebrafish 

Stem Cells International

Notch Inhibition Promotes Differentiation of Liver Progenitor Cells into Hepatocytes via sox9b Repression in Zebrafish

Figure 1