Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Ameliorates Nonalcoholic Fatty Liver Disease in Obese Type 2 Diabetic Mice
Human UC-MSC infusions improved glucose homeostasis. db/db mice were infused with human UC-MSCs or PBS once a week for six weeks. Blood glucose levels (a) and body weight (b) of the indicated groups were monitored once a week during the whole experiment period. (c) IPGTT was performed on the indicated groups to assess glucose tolerance. ^ indicates that the blood glucose level exceeded the maximum (33.3 mmol/l) of the glucometer. (d) IPITT was performed on the indicated groups to assess insulin tolerance, and the results were presented relative to the initial blood glucose levels. All the results are expressed as the . mice per group. ;. ns: not significant; IPGTT: intraperitoneal glucose tolerance tests; IPITT: intraperitoneal insulin tolerance tests.