CD73 Expression on Mesenchymal Stem Cells Dictates the Reparative Properties via Its Anti-Inflammatory Activity
Enhanced cardiac repair by CD73high pMSC in vivo. In comparison to the PBS control (MI-CON, ) and CD73low pMSC (), injection of CD73high pMSC () strikingly reinforced the wall thickness 28 days after transplantation (arrows in (a) and (c)). This result was further confirmed by echocardiography, showing robust thickening of the anterior wall (asterisk in (b)). Furthermore, the structural repair went in parallel with a functional improvement, showing a significant restoration of the ejection fraction and fractional shortening in comparison to the control and CD73low pMSC-treated animals (d). mm in (a). indicates and indicates compared to MI-CON. # indicates compared to CD73low pMSC.
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