CD73 Expression on Mesenchymal Stem Cells Dictates the Reparative Properties via Its Anti-Inflammatory Activity
Regulation of the local immune response by CD73high pMSC. The recruitment of immune cells in 5-day MI hearts was not altered by transplantation of either CD73low or CD73high pMSC (a). A subset of macrophages (CCR2+) was significantly diminished in amount in the CD73high-treated hearts (b). Notably, CD73high pMSC upregulated several anti-inflammatory-related genes (IL-4, IL-10, Arg-1, and TGM-2) and suppressed proinflammatory-related genes (TNF-α and NOS2). indicates and indicates compared to CD73low-treated hearts.
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