IL-10 Gene-Modified Human Amniotic Mesenchymal Stem Cells Augment Regenerative Wound Healing by Multiple Synergistic Effects

<div>Fluorescent image of frozen sections of wound skin. When exposed to green light, transplanted hAMSCs showed red fluorescence. When exposed to blue light, hAMSCs-IL-10 and hAMSCs-Null expressed green fluorescence. Labeled cells concentrated in subcutaneous tissues on day 14 after cell transplantation, indicating that hAMSCs-IL-10, hAMSCs, and hAMSCs-Null survived after transplantation. <span class="nowrap"><svg height="12.7373pt" id="M37" style="vertical-align:-3.429399pt" version="1.1" viewbox="-0.0498162 -9.3079 99.8059 12.7373" width="99.8059pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M409 504C401 567 396 607 392 642C354 654 312 665 266 665C137 665 60 583 60 487C60 374 161 325 225 290C300 250 355 215 355 141C355 68 311 21 235 21C131 21 86 122 71 183L41 176C48 128 61 42 68 21C78 16 93 8 118 0C142 -7 175 -15 216 -15C349 -15 438 69 438 174C438 287 344 333 265 374C186 414 138 449 138 522C138 576 172 631 249 631C336 631 363 562 380 499L409 504Z"></path></g><g transform="matrix(.013,0,0,-0.013,6.345,0)"><path d="M390 111C344 68 312 56 269 56C212 56 118 102 118 241C118 346 175 401 241 401C277 401 312 388 342 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Stem Cells International

fig10

Figure 10

Figure 10: IL-10 Gene-Modified Human Amniotic Mesenchymal Stem Cells Augment Regenerative Wound Healing by Multiple Synergistic Effects 