IL-10 Gene-Modified Human Amniotic Mesenchymal Stem Cells Augment Regenerative Wound Healing by Multiple Synergistic Effects

<div>Inflammatory cell infiltration of periwounds. (a) Histology of inflammatory cell infiltration in the dermis, showing decrease in hAMSC-treated groups on days 3, 7, and 14 compared with controls. The hAMSCs-IL-10 group had the lowest infiltration of inflammatory cells. No significant difference was seen between the hAMSCs-Null and hAMSC groups. Arrows indicate inflammatory cells. (b) Quantification of inflammatory cells in the dermis by groups at indicated time points. Infiltration of inflammatory cells into the dermis decreased after treatment with hAMSCs-IL-10 compared with hAMSCs, hAMSCs-Null, or control on days 3 and 7 and decreased with hAMSCs and hAMSCs-Null compared with the control. 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Stem Cells International

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Figure 4

Figure 4: IL-10 Gene-Modified Human Amniotic Mesenchymal Stem Cells Augment Regenerative Wound Healing by Multiple Synergistic Effects 