Identification of Macrophage Genotype and Key Biological Pathways in Circulating Angiogenic Cell Transcriptome

Figure 5

Analysis of EC-associated genes in the CAC_iv profile. (a) Boxplot comparing the relative expression of an endothelial gene set between CAC_iv and CD14⁺ monocytic cells. There is no significant difference in similarity of the genetic expression of CAC_iv or CD14⁺ monocytic cells to an EC-specific gene signature. (b) UHC analysis highlighting the relative expression of EC-associated genes in CAC_iv (grey) and monocytes (black). RNASE1 is indicated as most differentially expressed in CAC_iv compared to CD14⁺ monocytic cells. We observed a lack of consistency in EC-associated gene expression between different CAC_iv culture samples. Red: upregulation; green: downregulation.

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