Stem Cell-Derived Hepatocyte-Like Cells as Model for Viral Hepatitis Research

Table 2

Receptors and infection models of hepatitis viruses.

	HAV	HBV	HCV	HEV
Receptor	TIM-1 [48]	NTCP [46]	CD81, SR-BI, OCLN, CLDN1 [49–52]	Unknown
Cell model	HAV	HBV	HCV	HEV
PHH	+[53]	+[46]	+[54]	+[55]
HepG2	+[53]	+/–	–	+[56]
HepG2^NTCP	Unknown	+[46]	–	Unknown
HepaRG	Unknown	+[44]	–	+[57]
Huh7	Unknown	+/–	+/–	+[56]
Huh7^NTCP	Unknown	+[46]	+/–	Unknown
Huh7.5.1	Unknown	–	+[58, 59]	Unknown
HLCZ01	Unknown	+[60]	+[60]	Unknown
PLC/PRF5	Unknown	Unknown	Unknown	+[61]
A549	Unknown	–	–	+[61]
iPSC-derived HLC	Unknown	+[19, 62–64]	+[17, 65]	+[18, 66, 67]
hESC-derived HLC	Unknown	+[19]	+[17, 65]	+[18, 66, 67]

TIM-1: T-cell immunoglobulin and mucin domain 1; NTCP: sodium taurocholate cotransporting polypeptide; CD81: cluster of differentiation 81; SR-BI: scavenger receptor class B type I; OCLN: occluding; CLDN1: claudin-1; PHH: primary human hepatocyte; iPSC: induced pluripotent stem cell; hESC: human embryonic stem cell; HLC: hepatocyte-like cell. +: permissive; +/-: barely permissive; -: not permissive.