Immunomodulatory Functions of Mesenchymal Stem Cells in Tissue Engineering

Figure 3

MSCs regulate the differentiation of monocytes and differentiated low-expression Ly6c macrophages in liver fibrosis through the apoptosis of HSC and the secretion of MMP against the inflammatory fibrosis of the liver. Blue arrow: cells secrete cytokines. Green arrow: differentiation and alteration of monocytes and HSC. Dotted arrow: MSCs inhibit differentiation to high expression of Ly6c macrophage. Black arrow: positive promotion of cells and cytokines.