Flufenamic Acid Inhibits Adipogenic Differentiation of Mesenchymal Stem Cells by Antagonizing the PI3K/AKT Signaling Pathway

Figure 4

Treatment with 25 μM FFA suppresses adipose formation in the bone marrow of OVX and aged mice. (a) H&E staining of femurs from SHAM mice with N.S. treatment, SHAM mice with FFA treatment, OVX mice with N.S. treatment, and OVX mice with FFA treatment for 4 weeks. (b) Adipocyte count based on H&E staining of femurs in SHAM mice with N.S. treatment, SHAM mice with FFA treatment, OVX mice with N.S. treatment, and OVX mice with FFA treatment for 4 weeks. (c) Adipocyte area/tissue area based on H&E staining of femurs in SHAM mice with N.S. treatment, SHAM mice with FFA treatment, OVX mice with N.S. treatment, and OVX mice with FFA treatment for 4 weeks. (d) H&E staining of femurs in aged mice with N.S. treatment, and aged mice with FFA treatment for 4 weeks. (e) Adipocyte count based on H&E staining of femurs in aged mice with N.S. treatment, and aged mice with FFA treatment for 4 weeks. (f) Adipocyte area/tissue area based on H&E staining images of femurs in aged mice with N.S. treatment, and aged mice with FFA treatment for 4 weeks. . All data are shown as the, . compared with OVX mice with N.S. treatment (b, c). compared with aged mice with N.S. treatment (e, f). H&E.: hematoxylin and eosin.

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