Substance P Administered after Myocardial Infarction Upregulates Microphthalmia-Associated Transcription Factor, GATA4, and the Expansion of c-Kit<sup>+</sup> Cells

<div>The effects of FTY720 and RP67580 on SP-treated c-Kit<sup>+</sup> cells. (a) Graph indicating the proliferation of c-Kit<sup>+</sup> cells with one or both of these inhibitors, as identified using the EZ-Cytox cell viability assay kit. (b) Phase-contrast images of transwell migration assay for control and SP treatment with one or both of these inhibitors. 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-12Z"></path></g><g transform="matrix(.013,0,0,-0.013,43.785,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,50.025,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,56.265,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> versus corresponding controls using one-way analysis of variance (ANOVA) followed by Tukey’s post hoc tests or Student’s <span class="nowrap"><svg height="8.02022pt" id="M19" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 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(c) The effect of FTY720 and RP67580 on SP-stimulated c-Kit<sup>+</sup> cells pretreated with one or both of these inhibitors. Actin is the loading control. (d) Proposed model for the molecular mechanism of SP in LV repair post I/R.</div>

Stem Cells International

fig7

Figure 7

Figure 7: Substance P Administered after Myocardial Infarction Upregulates Microphthalmia-Associated Transcription Factor, GATA4, and the Expansion of c-Kit<sup>+</sup> Cells 

Figure 7 | Substance P Administered after Myocardial Infarction Upregulates Microphthalmia-Associated Transcription Factor, GATA4, and the Expansion of c-Kit+ Cells 