Research Article
Vitamin C Treatment Rescues Prelamin A-Induced Premature Senescence of Subchondral Bone Mesenchymal Stem Cells
Figure 4
Gene expression profile analysis of MSC/GFP and MSC/PLA. (a) Volcano plot showing the number of upregulated and downregulated genes on prelamin A overexpression. (b) Heatmap illustrating differentially expressed genes between replicates of MSC/GFP and MSC/PLA (passage 5). (c) KEGG enrichment analysis of upregulated genes in MSC/PLA. (d) Gene set enrichment analysis (GSEA) plots showing representative gene terms upregulated by prelamin A overexpression. (e) Heatmaps showing the transcriptional levels of genes enriched in various gene terms. (f) Quantitative RT-PCR verified the decreased expression of collagen I and collagen III in MSC/PLA ().
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