Functions of Circular RNAs in Regulating Adipogenesis of Mesenchymal Stem Cells

Table 1

Circular RNAs regulate adipogenic differentiation.

circRNA	miRNA or protein	Target gene(s)	Cell	Related process	Reference
Hsa_circ_0001946 (CDR1as)	miR-7-5p	Wnt5b	BMSCs	↑Adipogenesis; ↓Osteogenesis	[61]
Hsa_circ_0095570 (circH19)	PTBP1	SREBP1	hADSCs	↓Adipogenesis	[53]
CircFOXP1	miR-17-3p and miR-127-5p	Wnt5b and Wnt3a	BMSCs	↑Adipogenesis	[76]
circRNA 2: 27713879|27755789 and circRNA 2: 240822115|240867796	miR-328	C/EBPα	MC3T3-E1	↓Adipogenesis; ↑Osteogenesis	[77, 78]
	miR-23a-5p and miR-326	TGF-β
circRNA-11897	miR-27a and miR-27b	PPARγ	Adipocytes	↑Adipogenesis	[79]
circRNA-26852	miR-874	PPARα	Adipocytes	↑Adipogenesis	[79]
	miR-486	FOXO1
CiRS-133	miR-133	PRDM16	Preadipocytes	↑WAT browning	[80]
circRNA-0046366	miR-34a	PDGFRα	Adipocytes	↑Hepatocellular steatosis	[81, 82]
CircSAMD4A	miR-138-5p	EZH2	Preadipocytes	↑Adipogenesis	[83]