Adipose-Derived Mesenchymal Stem Cells Modulate Fibrosis and Inflammation in the Peritoneal Fibrosis Model Developed in Uremic Rats

Figure 3

Comparative analysis of α-SMA expression (employed to detect myofibroblasts by immunohistochemistry) and TGF-β, collagen III, and fibronectin gene expressions (achieved by quantitative real-time PCR) in the peritoneal membrane of all groups. CG-induced PF was associated with a significant increase in α-SMA expression in both the PF and PF+CKD groups (a) that also exhibited significant overexpression of TGF-β (b), collagen III (c), and fibronectin (d) genes. ASC treatment markedly reduced the peritoneal percentage of α-SMA, as well as the expression of genes related to fibrosis.

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