Human Adipose Derived Cells in Two- and Three-Dimensional Cultures: Functional Validation of an In Vitro Fat Construct

Figure 7

Implantation of ObaGel for the development of a humanized fat pad in mice. Scaffolds remained in mice for 6 weeks. Hematoxylin and eosin staining revealed a dense confinement of proliferating cells within the silk scaffolds. In contrast, ObaGel implants contained large blood vessels that were clearly integrated functionally within larger, more mature adipocytes.