Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis

Table 1

Extracellular vesicle miRNA cargo and MSC-mediated angiogenesis.

MicroRNA	MSC (tissue of origin)	Function	Reference
miR148a, miR532-5p, miR378, let-7f	Porcine adipose tissue	Putative tissue regeneration by inducing several cellular pathways including angiogenesis	[71]
miR494	Human bone marrow	Muscle regeneration by enhancing myogenesis and angiogenesis	[64]
miR-19a	Rat bone marrow (GATA-4-overexpressing MSC)	Cardioprotection by increasing survival and angiogenesis	[72, 73]
miR-125a	Human adipose tissue	Induction of angiogenesis through the repression of DLL4 expression	[65]
miR-210	Mouse bone marrow	Promotion of angiogenesis in a mouse myocardial infarction model through the repression of Efna3 expression in endothelial cells	[66, 74]
miR-30b	Not available	Promotion of angiogenesis in vitro and in vivo	[75]
miR-21a-5p	Mouse bone marrow	Cardioprotection through inhibition of proapoptotic genes; in silico data support a role in angiogenesis	[76]
miR-210-3p	Mouse bone marrow	Acceleration of recovery of hindlimb ischemia through the promotion of angiogenesis	[50]
miR-31	Human adipose tissue	Promotion of angiogenesis in HUVECs by targeting the antiangiogenic HIF-1 gene	[77]
miR-181b	Rat adipose tissue	Promotion of the mobility and angiogenesis of brain microvascular endothelial cells (BMECs) after oxygen-glucose deprivation (OGD) through the repression of TRPM7 expression	[63]
miR-21-5p	Human endometrium	Cardioprotection and enhancing microvessel density in a rat model of myocardial infarction	[78]