Curcumin-Activated Mesenchymal Stem Cells Derived from Human Umbilical Cord and Their Effects on MPTP-Mouse Model of Parkinson’s Disease: A New Biological Therapy for Parkinson’s Disease

Figure 7

CM-CUR protect against MPTP-induced degeneration of PD model cells. (a) The proliferation of the SH-SY5Y cells in the model group was significantly declined ( vs. normal cells), whereas increased after treatment with CM-MSC and CM-CUR at 24 and 48 h (; ). At 24 h, the CM-MSC and CM-CUR groups did not display any significant difference. At 48 h, the proliferation in the CM-CUR group significantly exceeded that of the CM-MSC group (). (b) Flow cytometry showed that the rate of apoptosis in SH-SY5Y cells was , in the model group, in the CM-CUR group, and in the CM-MSC group. After CM-MSC and CM-CUR were added to the normal SH-SY5Y cells, the proliferation was lower, at and , respectively. (c) There were significant differences between the normal and model cells (). The apoptosis rate of SH-SY5Y cells in the CM-MSC and CM-CUR groups was significantly lower compared with the model group (), especially in the CM-CUR group. There were differences between the CM-MSC group and the CM-CUR group () (two-way analysis of variance, Newman-Keuls test). All experiments were performed thrice.

(a)

(b)

(c)