Hypoxic Wharton’s Jelly Stem Cell Conditioned Medium Induces Immunogenic Cell Death in Lymphoma Cells

<div>(a) Apoptotic assay (dot plots) of lymphoma cells after treatment with normoxic and hypoxic hWJSC-CM. Note significant increases in percentages of AV+PI- and AV+PI+ of lymphoma cells after treatment with hWJSC-CM as compared to the control. Treatment with hWJSC-CM collected under 5% oxygen condition showed the highest percentage increase in AV+PI- and AV+PI+ cells. (b, c) Flow cytometry dot plots and percentage caspase activity showed significant increases in caspase 3, caspase 8, and caspase 9 activities in lymphoma cells after treatment with hWJSC-CM as compared to the control. Treatment with hWJSC-CM collected under 5% oxygen conditions showed the highest increase in all caspase activities in lymphoma cells. 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Stem Cells International

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Figure 2

Figure 2: Hypoxic Wharton’s Jelly Stem Cell Conditioned Medium Induces Immunogenic Cell Death in Lymphoma Cells 