Mechanical Strain-Mediated Tenogenic Differentiation of Mesenchymal Stromal Cells Is Regulated through Epithelial Sodium Channels

<div>Proposed mechanism for the regulation of hMSCs tenogenic differentiation signaling pathways by ion channel ENaC. (b) ENaC leads to upregulation of the tenogenic gene markers, which in turn activates the tenogenic differentiation signaling pathway. Benzamil (a) which is the ENaC inhibitor, inhibits this pathway, and thus influences the cell differentiation.</div>

Stem Cells International

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Figure 6

Figure 6: Mechanical Strain-Mediated Tenogenic Differentiation of Mesenchymal Stromal Cells Is Regulated through Epithelial Sodium Channels 