circRNA Expression Profile in Dental Pulp Stem Cells during Odontogenic Differentiation

Figure 2

Differentially expressed circRNAs between different groups, differentially expressed circRNAs validated by qRT-PCR. (a) Hierarchical cluster analysis of circRNAs in the induced and noninduced groups by gene chip. The parts of red and green, respectively, mean the upregulation and downregulation of circRNA. (b) Box plot indicated that the distribution of the intensities among all samples was nearly the same. (c) Red font in the volcano plot denotes the differentially expressed circRNAs with statistical significance from hDPSCs between the induced and noninduced groups ( or <-1.5, ). (d–g) circRNA hsa_circRNA_104101, hsa_circRNA_406763, hsa_circRNA_002161, and hsa_circRNA_005044 were upregulated in the induced group in comparison with the noninduced group. (h, i) circRNAs hsa_circRNA_079813 and hsa_circRNA_008336 were downregulated. The data were represented as . , , , and . (j) Results of the comparison of microarray and qRT-PCR data for candidate circRNAs.

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