circRNA Expression Profile in Dental Pulp Stem Cells during Odontogenic Differentiation

Figure 3

circRNA-miRNA-mRNA network. Several most significantly different circRNAs were selected from the results of the gene chip, miRanda, and Targetscan software which were used to determine the circRNAs combined with miRNAs, and TargetScan, miRDB, CircBase, and CircBank were used to predict target mRNAs. (a) CeRNA networks of upregulated circRNAs-miRNAs-mRNAs, included 5 circRNAs, 19 miRNAs, and 363 mRNAs. Yellow circle represents circRNAs, purple circle represents miRNAs, green circle represents underlying target mRNAs, and the lines indicate interactions between circRNAs and miRNAs or miRNAs and mRNAs. (b) CeRNA networks of downregulated circRNAs-miRNAs-mRNAs, included 4 circRNAs, 16 miRNAs, and 258 mRNAs. Orange circle represents circRNAs, light green circle represents miRNAs, pink circle represents underlying target mRNAs, and the lines indicate interactions between circRNAs and miRNAs or miRNAs and mRNAs.

(a)

(b)