Exosomes from Placenta-Derived Mesenchymal Stem Cells Are Involved in Liver Regeneration in Hepatic Failure Induced by Bile Duct Ligation

Figure 5

The effect of PD-MSC and CRP for WB-F344 in the protein level. The protein levels of CRP, VEGF, Wnt signaling factors, and ALB were detected in WB-F344s treated with LCA and cocultivated with HUVECs and PD-MSCs (a). Graph of intensity was normalized to that of actin for CRP (b), VEGF (c), pGKS3αβ (d), β-catenin (e), and ALB (f) ( per group, control group and ^#LCA-treated group vs. ). Data were represented as the . Representative images of immunofluorescence were stained with WB-F344s for CRP and β-catenin after LCA or recombinant CRP treatment, transfection of siRNA-CRP, and cocultivation of PD-MSCs (g). Scale bars: 20 μm. ALB: albumin; LCA: lithocholic acid-treated group; PD-MSC: PD-MSC cocultivated group.

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