Retinoic Acid Signal Negatively Regulates Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells

<div>Blocking RA signal enhances the expression of osteo/odontogenic related factors from human DPSCs in vivo. Immunohistochemical (IHC) staining reveals expression levels of DSPP (a, b), OCN (d, e), and COL-1 (g, h). Qualitative measurements of IHC staining show expressions of DSPP (c), OCN (f), and COL-1 (i) are enhanced significantly by BMS 493 treatment. 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Stem Cells International

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Figure 5

Figure 5: Retinoic Acid Signal Negatively Regulates Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells 