Radiation Induces Pulmonary Fibrosis by Promoting the Fibrogenic Differentiation of Alveolar Stem Cells

<div>Nintedanib attenuates radiation-induced pulmonary cell fibrogenic differentiation. (a, b) LSCs and LSC-differentiated alveolar cells were exposed to 4 Gy followed by treatment with or without nintedanib (1 <i>μ</i>M) and then incubated for 3 days. The levels of SP-C (red) and <i>α</i>-SMA (green) protein were determined by coimmunostaining. The arrowheads indicate SP-C<sup>+</sup>/<i>α</i>-SMA<sup>+</sup> cells. The nuclei of cells were stained blue with DAPI. Scale bars, 75 <i>μ</i>m.</div>

Stem Cells International

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Figure 5

Figure 5: Radiation Induces Pulmonary Fibrosis by Promoting the Fibrogenic Differentiation of Alveolar Stem Cells 