Cathepsin K Deficiency Impaired Ischemia-Induced Neovascularization in Aged Mice

<div>Aging resulted in impaired capillary formation and blood flow recovery in response to ischemia in the muscles of C57BL/6J mice. (a) Representative LSBFI result and quantitative data show the ratio of ischemia to nonischemia blood flow in young (8-week-old) and aged (96-week-old) CatK<sup>+/+</sup> mice. (b) Representative images show the capillary density in nonischemic and ischemic thigh adductor muscles. (c) Quantitative analyses revealed that CatK<sup>−/−</sup> impaired the capillary density in the ischemic muscle. 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Stem Cells International

fig1

Figure 1

Figure 1: Cathepsin K Deficiency Impaired Ischemia-Induced Neovascularization in Aged Mice 