Review Article
Dental Stem Cell-Derived Secretome/Conditioned Medium: The Future for Regenerative Therapeutic Applications
Table 2
Summary of the included studies investigating the effect of dental MSCs’ secretome/conditioned medium on treating skin and internal diseases.
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ABCB4: phosphatidylcholine translocator; Adipsin: complement factor D; ANG: angiogenin; APC: adenomatous polyposis coli protein; APOA: apolipoprotein A; APOBR: apolipoprotein B receptor; APOC3: apolipoprotein C-III; B2M: β2-microglobulin; BDNF: brain-derived neurotrophic factor; bFGF: basic fibroblast growth factor; CD: cluster of differentiation; CM: conditioned medium; CTSS: cathepsin S; CXCL16; chemokine (C–X–C motif) ligand 16; Dkk-1: Dickkopf 1; Dkk-3: Dickkopf 3; ED-Siglec-9: ectodomain of sialic acid-binding Ig-like lectin-9; EGF: epidermal growth factor; EGFR: epithelial growth factor receptor; EG-VEGF: endocrine-gland-derived vascular endothelial growth factor; EXs: exosomes; FGF: fibroblast growth factor; Flt-3 L: Fms-like tyrosine kinase receptor-3; FSTN: follistatin; GAS6: growth arrest-specific protein 6; GDF-15: growth differentiation factor 15; GDNF: glial cell line-derived neurotrophic factor; GRO: chemokine (C–X–C motif) ligand 1; HGF: hepatocyte growth factor; HGFR: hepatocyte growth factor receptor; HNF4G: hepatocyte nuclear factor 4 gamma; HVEM: herpesvirus entry mediator; IGF-1: insulin-like growth factor 1; IGFBP: insulin-like growth factor binding protein; IL: interleukin; IL-1RA: interleukin-1 receptor antagonist; LAP: latency-associated peptide; LPA: lipoprotein A; LRP10: LDL receptor-related protein 10; LRP1B: low-density lipoprotein-related protein 1B; LRP3: LDL receptor-related protein 3; LRP4: LDL receptor-related protein 4; LRP5: LDL receptor-related protein 5; LRP6: LDL receptor-related protein 6; LRP8: LDL receptor-related protein 8; MCP-1: monocyte chemoattractant protein-1; MCP-3: monocyte chemoattractant protein-3; MIF: macrophage migration inhibitory factor; MIP-1β: macrophage inflammatory protein 1β; MMP: matrix metalloprotease; mRNA: messenger RNA; MSCs: mesenchymal stem cells; mTOR: mammalian target of rapamycin; NFATc1: nuclear factor of activated T cells 1; NID-1: nidogen-1; OPG: osteoprotegerin; OSM: oncostatin M; PAI-1: plasminogen activator inhibitor-1; PDGF: platelet-derived growth factor; PEG10: retrotransposon-derived protein; RAGE: receptor for AGEs; RANK: receptor activator of nuclear factor-κB; RANKL: receptor activator of nuclear factor-κB ligand; SCF: stem cell factor; SDF-1: stromal cell-derived factor 1; MSCs: mesenchymal stem cells; SHED: stem cells derived from human exfoliated deciduous teeth; sIL-6R: soluble interleukin-6 receptor; spg130: soluble glycoprotein 130; sTNFR1: soluble tumor necrosis factor receptor 1; TGF-β: transforming growth factor-β; TIMP: tissue inhibitor of metalloproteinases; TNF-α: tumor necrosis factor alpha; TRAP: tartrate-resistant acid phosphatase; TWEAK: TNF-related weak inducer of apoptosis; uPAR: urokinase plasminogen activator surface receptor; VEGF: vascular endothelial growth factor. |