Review Article
Dental Stem Cell-Derived Secretome/Conditioned Medium: The Future for Regenerative Therapeutic Applications
Table 4
Summary of the included studies investigating the effect of dental MSCs’ secretome/conditioned medium on bone regeneration.
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3D: three dimensional; ADAM19: disintegrin and metalloproteinase domain-containing protein; ASF1A: anti-silencing function 1A histone chaperone; ATP2B4: plasma membrane calcium transporting ATPase 4; BCAP29: B-cell receptor-associated protein 29; BEST3: bestrophin-3; BMP: bone morphogenetic protein; BMP2K: BMP2-inducible kinase; BMPR1A: bone morphogenetic protein receptor type-1A; CCDC47: coiled-coil domain containing 47; CHRDL1: chordin-like 1; CM: conditioned medium; COL1A1: collagen type 1; COL27A1: collagen alpha-1(XXVII) chain; DDR2: discoidin domain receptor family, member 2; DSPP: dentin sialophosphoprotein; ENAM: enamelin; ERCC2: ERCC excision repair 2; TFIIH: core complex helicase subunit; EVs: extracellular vesicles; FAM20C: Golgi-associated secretory pathway kinase; FBN1: fibrillin 1; FHL2: four and a half LIM domains 2; GDF-5: growth differentiation factor 5; HDAC7: histone deacetylase 7; HIRA: histone cell cycle regulator; ID3: inhibitor of DNA binding 3; IFT80: intraflagellar transport 80; IMPAD1: inositol monophosphatase domain containing 1; INHBA: inhibin beta A chain inhibitor-1; ITGB3: integrin beta-3; JAG1: jagged 1; LEP: leptin; LRP4: LDL receptor-related protein 4; MEF2C: myocyte enhancer factor 2C; MSCs: mesenchymal stem cells; MINPP1: multiple inositol polyphosphate phosphatase 1; MMP: matrix metalloprotease; MYBBP1A: MYB-binding protein 1a; PDLIM7: PDZ and LIM domain 7; PEI: polyethylenimine; PEX7: peroxisomal biogenesis factor 7; PLA: polylactide; RHOA: Ras homolog family member A; ROR2: RTK-like orphan receptor 2; RPL38: ribosomal protein L38; RUNX2: runt-related transcription factor 2; SAMD9: sterile alpha motif domain containing protein 9; MSCs: mesenchymal stem cells; SFRP1: secreted frizzled-related protein 1; SIX2: SIX homeobox 2; SMAD1: SMAD family member 1;SNAI1: snail family transcriptional repressor 1; SOX: sex-determining region Y-box; SUCO: SUN domain-containing ossification factor; TFIP11: tuftelin-interacting protein 11; TGF-β: transforming growth factor-β; TOB2: transducer of ERBB2; TUFT1: tuftelin 1; TWSG1: twisted gastrulation BMP signaling modulator 1; USP9X: USP9X protein variant; VEGF: vascular endothelial growth factor; VEGFR2: vascular endothelial growth factor receptor 2; WISP2: WNT1-inducible signaling pathway protein 2; ZNF423: zinc finger protein 423; ZNF521: ZNF521 protein. |