Concise Review: The Regulatory Mechanism of Lysine Acetylation in Mesenchymal Stem Cell Differentiation

Table 2

Acetylation regulation of mesenchymal stem cell differentiation into adipose cells.

Adipogenesis
Epigenetic mark/enzymatic function	Specific chromatin modifier	Targeted stem cell population	Differentiation	Refs.
Deacetylation
	HDAC3	3 T3-L1	Attenuates adipogenesis by binding to the master regulator PPARγ and attenuating PPARγ’s capacity to drive gene expression	[56, 58]
	Sirt1	Mice bone marrow	Attenuates adipogenesis by binding to the master regulator PPARγ and repressing its target genes	[62, 63, 65–72]
				[66]