Aging Induced p53/p21 in Genioglossus Muscle Stem Cells and Enhanced Upper Airway Injury

Figure 7

The diagrammatic sketch shows the damage mechanism of hypoxia and aging to genioglossus. Under hypoxia, increasing p53 and p21 induce the decline of MyoD. Then, low expression of MyoD leads to the reduction of myotube formation, especially in aging MuSCs. Finally, the results above enhance upper airway muscle injury.