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| Application | ADSC source | Administration route | Animal model | Results |
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Arrigoni et al. [58] | Bone | Rabbit | Surgical implantation | Rabbit | Bone formation with the ADSC was demonstrated by a significant increase in bone content |
Chen et al. [48] | Bone | Human | Surgical implantation | Mice | Overexpression of miR-375 significantly enhanced ADSC osteogenesis both in vitro and in vivo |
Li et al. [84] | Cartilage | Human | (i) Injection (ii) Surgical implantation | Rat | ADSCs showed a better inflammation-modulating property |
Rabbit | ADSCs with scaffold promoted cartilage regeneration in the long term |
Cho et al. [49] | Cartilage | ā | Surgical implantation | Rabbit | The quality of regenerative cartilage significantly improved in the ADSC group |
Huurne et al. [101] | Cartilage | Mouse | Injection | Mice | The ADSC-based treatment could inhibit synovial thickening, the formation of enthesophytes associated with ligaments, and cartilage destruction |
Yin et al. [107] | Cartilage | Rabbit | Surgical implantation | Rabbit | ADSCs containing the TGF immobilized scaffold better-promoted cartilage regeneration in defective articular cartilage |
Hu et al. [113] | Nerve | Rat | Surgical implantation | Rat | Improved nerve regenerative ability for ADSC group compared to control |
Kingham et al. [114] | Nerve | Human | Surgical implantation | Rat | Both ADSCs and stimulated-ADSCs could promote axon regeneration |
Li et al. [116] | Nerve | Rat | Injection | Rat | ADSCs alleviated neurological deficits and reduced brain water content in rats |
Durco et al. [132] | Nerve | Human | Surgical implantation | Mice | The number of nerve fibers and motor plates was higher in the ADSC group |
Nagata et al. [134] | Myocardium | Mice | Transfusion | Mice | The transfusion of ADSCs exhibited the highest cardiac functional recovery and the high frequency of the recruitment to ischemic myocardium |
Bobi et al. [140] | Myocardium | Pig | Injection | Pig | Myocardial perfusion at the anterior infarct border increased in ADSC-treated animals |
Mori et al. [141] | Myocardium | Human | Surgical implantation | Porcine | Left ventricular remodeling attenuated and vascular density increased in the infarct border area in the ADSC group |
Qiao et al. [145] | Myocardium | Rat | Injection | Rat | ADSC and dECM groups could increase angiogenesis, reduce the degree of fibrosis, and decrease infarct size |
Ge et al. [151] | Liver | Pig | Injection | Pig | AST, ALT, T-BIL, and LDH were significantly decreased in ADSC treatment |
Jiao et al. [152] | Liver | Pig | Injection | Pig | ADSC transplantation ameliorated the IRI-induced histopathological damage |
Zhang et al. [153] | Liver | Pig | Injection | Pig | ADSC group promoted liver function recovery, reduced oxidative stress, and promoted liver regeneration |
Yan et al. [154] | Liver | Canine | Injection | Canine | AST and ALT were rapidly decreased in ADSC treatment |
Nishiwaki et al. [162] | Skin | Mice | Surgical implantation | Mice | ADSCs contributed to wound healing in a dorsal skin defect model in diabetic mice |
Xiong et al. [165] | Skin | Human | Injection | Mice | ADSCs significantly accelerated the healing of skin wounds by promoting cell proliferation |
Chou et al. [169] | Skin | Rat | Injection | Rat | The wound treated with ADM-ADSCs showed a significantly higher wound healing rate than other groups |
Yu et al. [172] | Skin | Human | Surgical implantation | Mice | The neoskin formed in the presence of ADSC exhibited a thickness comparable to normal skin and possessed a highly organized collagen structure |
Nakamura et al. [180] | Trachea | Rat | Surgical implantation | Rat | The mucociliary transport function was improved by ADSC transplantation |
Jin et al. [181] | Bladder | Rat | Surgical implantation | Rat | The rat bladder repair effect was better in the ADSC group |
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