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| Study title | Conditions | Interventions | Status | Locations |
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| 1 | The application of cultured cornea stem cells in patients suffering from corneal stem cell insufficiency | Unilateral limbal stem cell insufficiency | Procedure: transplant of cultured limbal stem cells on the cornea | Terminated | National Taiwan University Hospital, Department of Ophthalmology, Taipei, Taiwan |
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| 2 | The application of oral mucosal epithelial cell sheets cultivated on amino membrane in patients suffering from corneal stem cell insufficiency or symblepharon | Limbal insufficiency
Symblepharon | Procedure: cultured oral mucosa cell sheet transplantation | Terminated | National Taiwan University Hospital, Department of Ophthalmology, Taipei, Taiwan |
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| 3 | Limbus-derived stem cells for prevention of postoperative corneal haze | Corneal scars and opacities | Biological: stem cells
Other: vehicle | Recruiting | LV Prasad Eye Institute, Hyderabad, Telangana, India |
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| 4 | The improvement of limbal stem cell deficiency (LSCD) in unilateral stem cell damage by amniotic membrane extract eye drop (AMEED) | Limbal stem cell deficiency (LSCD) | Biological: amniotic membrane extract eye drop (AMEED) | Completed | — |
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| 5 | Efficacy and safety of autologous cultivated limbal stem cells transplantation (ACLSCT) for restoration of corneal epithelium in patients with limbal stem cell deficiency | Limbal stem cells deficiency | Biopsy from donor eye
Implant of Holoclar
Ophtalmologic examination (and 5 more) | Recruiting | Hospital San Raffaele, Milan, Italy |
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| 6 | Stem cells therapy for corneal blindness | Corneal injuries
Corneal burns
Corneal scars and opacities | Biological: ex vivo cultivated limbal stem cell pool | Unknown | LV Prasad Eye Institute, Hyderabad, Telangana, India |
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| 7 | Autologous cultured corneal epithelium (CECA) for the treatment of limbal stem cell deficiency | Limbal stem cell deficiency | Procedure: surgical transplantation of CECA | Recruiting | CIUSSS de l’Est de l’île de Montréal, Quebec, Canada
Centre Universitaire d’Ophtalmologie CHU de Québec-HSS Québec, Canada |
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| 8 | Autologous adipose-derived adult stem cell transplantation for corneal diseases | Hereditary corneal dystrophy
Keratoconus | Procedure: lipoaspiration
Procedure: transplantation | Unknown | Optica General, Saida, Lebanon |
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| 9 | Corneal epithelial autograft for LSCD | Limbal stem cell deficiency | Corneal epithelial and limbal conjunctival autograft
Femtosecond laser and diamond knife | Recruiting | Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China |
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| 10 | Umbilical cord mesenchymal stem cells injection for ocular corneal burn | Ocular corneal burn | Biological: human umbilical cord mesenchymal stem cells
Biological: placebo | Unknown | The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China |
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| 11 | Follow-up study after ACLSCT for restoration of corneal epithelium in patients with LSCD due to ocular burns | Limbal stem cell deficiency due to ocular burn | Procedure: ophthalmologic examinations
Other: digital pictures
Other: QoL questionnaires | Recruiting | Hospital San Raffaele, Milan, Italy |
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| 12 | Corneal epithelium repair and therapy using autologous limbal stem cell transplantation | Corneal disease
Pterygium
Myopia
Hyperopia | LSCs and amniotic membrane (modified technique); amniotic membrane only (traditional technique); PRK, LSCs, and amniotic membrane (modified technique) (and 4 more) | Unknown | Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China |
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| 13 | Corneal epithelial stem cells and dry eye disease | Dry eye syndromes
Dry eye ocular inflammation (and 3 more) | Other: corneal epithelial stem cell transplant | Enrolling by invitation | Rush Eye Associates, Amarillo, Texas, United States |
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| 14 | Efficacy of cultivated corneal epithelial stem cell for ocular surface reconstruction | Severe ocular surface damage
Limbal deficiency | Procedure: cultivated limbal transplantation | Completed | Pinnita Prabhasawat, MD, Bangkok, Thailand |
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| 15 | Corneal epithelial allograft from living-related donor for LSCD | Limbal stem cell deficiency | Procedure: corneal epithelial allograft
Procedure: limbal conjunctival allograft
Device: femtosecond laser
Device: diamond knife | Completed | Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China |
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| 16 | The treatment of human bone marrow mesenchymal stem cells in ocular corneal burn | Chemical burns | Other: human bone marrow MSC | Completed | — |
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| 17 | Clinical trial on the effect of autologous oral mucosal epithelial sheet transplantation | Limbal stem cell deficiency
Stevens-Johnson syndrome
Ocular cicatricial pemphigoid
Chemical burn | Biological: cultivated oral mucosal epithelial sheet transplantation | Available | Seoul National University Hospital, Seoul, Republic of Korea |
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| 18 | Cultivated limbal epithelial transplantation (CLET) for limbal stem cell deficiency (LSCD) | Limbal stem cell deficiency | — | Not yet recruiting | IOBA, Valladolid, Spain |
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| 19 | Limbal stem cell deficiency (LSCD) treatment with cultivated stem cell (CALEC) graft | Limbal stem cell deficiency | Procedure: biopsy to collect limbal epithelial stem cells that will be cultivated into a graft
Biological: cultivation of limbal epithelial cells into a graft
Procedure: CALEC transplant
Procedure: CLAU | Recruiting | Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States |
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