Efficacy and Safety of Mesenchymal Stem Cells in Treatment of Complex Perianal Fistulas: A Meta-Analysis

Table 1

Summary of the eligible randomized controlled trials.

(a)

Study	Type of perianal fistula		Cell type and source	Outcome	Results (healed)
Garcia-Olmo et al. [14]; (2009); Spain	(1) Crohn; (2) Cryptoglandular	49	Autologous ASCs	Reepithelialization	17/24 vs. 4/25 CD: 5/7 MSCs+fibrin glue vs. 1/7 fibrin glue at 8 w; cryptoglandular: 12/17 MSCs+fibrin glue vs. 3/18 fibrin glue at 8 w;
Guadalajara et al. [16]; (2012); Spain	(1) Crohn; (2) Non-CD	30	Autologous ASCs	Reepithelialization+MRI	10/18 vs. 3/12 CD: 2/4 MSCs+fibrin glue vs. 1/2 fibrin glue at 40 m;
Herreros et al. [17]; (2012); Spain	Cryptoglandular	183	Autologous ASCs	Reepithelialization+MRI	51/124 vs. 22/59 25/64 MSCs+26/60 MSCs+fibrin glue vs. 22/59 fibrin glue at 24 w
Molendijk et al. [22]; (2015); Netherlands	Crohn	21	Allogeneic BMSCs	Reepithelialization+MRI	7/15 MSCs vs. 2/6 saline solution at 12 w
Panés J [23] (2016); Israel	Crohn	212	Allogeneic ASCs	Reepithelialization+MRI	53/103 MSCs vs. 36/101 saline solution at 24 w
Panés J [26] (2018); Israel	Crohn	212	Allogeneic ASCs	Reepithelialization+MRI	58/103 MSCs vs. 39/101 saline solution in 52 w
Garcia-Arranz M [27] (2019); Spain	Cryptoglandular	35	Autologous ASCs	Reepithelialization	10/20 MSCs+fibrin glue vs. 5/19 fibrin glue at 2 years

(b)

Intervention (mean)	Recurrence	Refractory	AEs	Use of concurrent (anti-TNF)
Fixed cell dose	7 months without recurrence	Yes		Yes
First: MSCs
Second: MSCs
Fixed cell dose	Two completely healed patients were followed up for 4 years without recurrence	Yes		Yes
First: MSCs
Second: MSCs
Fixed cell dose	Unknown	Yes		No
First: MSCs
Second: MSCs
Fixed cell dose	24 w without recurrence	Yes		Yes
A: MSCs
B: MSCs
C: MSCs
Fixed cell dose	Being follow-up	Yes	68/103 in MSCs vs. 66/102 in placebo at 24 w	Yes
MSCs
Fixed cell dose	Being follow-up	Yes	79/103 in MSCs vs. 74/102 in placebo at 52 w	Yes
MSCs
Fixed cell dose	Recurrence of the fistula was observed at 2-year follow-up in eight previously cured patients	Unknown	7/23 MSCs+fibrin glue vs. 9/21 fibrin glue	No
First: MSCs
Second: MSCs