Stem Cells International / 2020 / Article / Tab 1

Review Article

Efficacy and Safety of Mesenchymal Stem Cells in Treatment of Complex Perianal Fistulas: A Meta-Analysis

Table 1

Summary of the eligible randomized controlled trials.
(a)

StudyType of perianal fistulaCell type and sourceOutcomeResults (healed)

Garcia-Olmo et al. [14]
(2009)
Spain
(1) Crohn
(2) Cryptoglandular
49Autologous ASCsReepithelialization17/24 vs. 4/25 CD: 5/7 MSCs+fibrin glue vs. 1/7 fibrin glue at 8 w; cryptoglandular: 12/17 MSCs+fibrin glue vs. 3/18 fibrin glue at 8 w;
Guadalajara et al. [16]
(2012)
Spain
(1) Crohn
(2) Non-CD
30Autologous ASCsReepithelialization+MRI10/18 vs. 3/12 CD: 2/4 MSCs+fibrin glue vs. 1/2 fibrin glue at 40 m;
Herreros et al. [17]
(2012)
Spain
Cryptoglandular183Autologous ASCsReepithelialization+MRI51/124 vs. 22/59 25/64 MSCs+26/60 MSCs+fibrin glue vs. 22/59 fibrin glue at 24 w
Molendijk et al. [22]
(2015)
Netherlands
Crohn21Allogeneic BMSCsReepithelialization+MRI7/15 MSCs vs. 2/6 saline solution at 12 w
Panés J [23] (2016)
Israel
Crohn212Allogeneic ASCsReepithelialization+MRI53/103 MSCs vs. 36/101 saline solution at 24 w
Panés J [26] (2018)
Israel
Crohn212Allogeneic ASCsReepithelialization+MRI58/103 MSCs vs. 39/101 saline solution in 52 w
Garcia-Arranz M [27] (2019)
Spain
Cryptoglandular35Autologous ASCsReepithelialization10/20 MSCs+fibrin glue vs. 5/19 fibrin glue at 2 years


(b)

Intervention (mean)RecurrenceRefractoryAEsUse of concurrent (anti-TNF)

Fixed cell dose7 months without recurrenceYesYes
 First: MSCs
 Second: MSCs
Fixed cell doseTwo completely healed patients were followed up for 4 years without recurrenceYesYes
 First: MSCs
 Second: MSCs
Fixed cell doseUnknownYesNo
 First: MSCs
 Second: MSCs
Fixed cell dose24 w without recurrenceYesYes
 A: MSCs
 B: MSCs
 C: MSCs
Fixed cell doseBeing follow-upYes68/103 in MSCs vs. 66/102 in placebo at 24 wYes
MSCs
Fixed cell doseBeing follow-upYes79/103 in MSCs vs. 74/102 in placebo at 52 wYes
MSCs
Fixed cell doseRecurrence of the fistula was observed at 2-year follow-up in eight previously cured patientsUnknown7/23 MSCs+fibrin glue vs. 9/21 fibrin glueNo
 First: MSCs
 Second: MSCs