Research Article

Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants

Table 1

Characteristics of the studies included in this meta-analysis.

Author, yearType of animalType of injuryMSC typeNumber of MSCRoute of deliveryEndpoints for this meta-analysis

Herrera 200424MiceGlycerol-inducedBM-MSCsIntravenous injectionScr
Bi 200712MiceCisplatin-inducedBM-MSCsIntravenous injection or intraperitoneal injectionScr, BUN
Sun 200840RatGlycerol-inducedBM-MSCsAbdominal aorta injectionScr, BUN
Qian 20086RatGlycerol-inducedBM-MSCsIntravenous injectionScr
Magnasco 200822RatAdriamycin-inducedBM-MSCsIntravenous injectionScr, BUN, UAE, renal damage score
Bruno 200916MiceGlycerol-inducedBM-MSCsIntravenous injectionScr, BUN, MDA, GSH, SOD, renal damage score
Eliopoulos 201010MiceCisplatin-inducedBM-MSCsIntraperitoneal injectionScr, BUN
Kim 201217RatCisplatin-inducedAD-MSCsIntravenous injectionScr, BUN
Zickri 201230RatAdriamycin-inducedhUC-MSCsIntravenous injectionScr
Sarhan 201419RatAdriamycin-inducedBM-MSCsIntravenous injectionScr, BUN, UAE, renal pathology, MDA, GSH
Moustafa 201680RatCisplatin-inducedBM-MSCsIntravenous, intraarterial or kidney subcapsular injectionScr, MDA, GSH, SOD
Elhusseini 201640RatCisplatin-inducedAD-MSCsIntravenous injectionScr, BUN, Ccr, renal pathology, MDA, GSH, SOD
Anan 201613RatAdriamycin-inducedBM-MSCsIntravenous injectionScr, BUN, SOD
Gad 201724RatMethotrexate-inducedBM-MSCsIntraperitoneal injectionScr, BUN, MDA, GSH
Rashed 201820RatStreptozotocin -inducedBM-MSCsIntravenous injectionScr, BUN, UAE, Ccr
Elbaghdady 201820RatCadmium chloride-inducedBM-MSCsIntravenous injectionScr
Danjuma 201816RatRifampicin-inducedBM-MSCsIntravenous injectionScr, BUN
Putra 201910RatGentamicin inducedhUC-MSCsIntraperitoneal injectionScr, BUN, renal pathology
Cetinkaya 201917RatAristolochic acid inducedhAMSCIntravenous injectionScr, BUN
Selim 201970RatCisplatin-inducedAD-MSCs; BM-MSCsIntravenous injectionScr, BUN
Mata-Miranda 201910MiceCisplatin-inducedmESCsIntraperitoneal injectionScr
Vazquez-Zapien 201919MiceCisplatin-inducedmESCsIntraperitoneal injectionScr
Minocha 20193RatCisplatin-inducedAFSCIntravenous injectionScr, BUN
Sun B 201910RatCisplatin-inducedUSCsIntravenous injectionScr
Sun 20196RatCisplatin-inducedBM-MSCsRenal parenchyma injectionScr, BUN
Zhang 20209RatCisplatin-inducedUSCsSubcutaneous injectionScr, Ccr, renal pathology
Foroutan 20206RatCisplatin-inducedBM-MSCsIntraperitoneal injectionScr, BUN

Note: BM-MSCs: bone marrow mesenchymal stem cells; hAMSCs: human amnion-derived mesenchymal stem cells; hUC-MSCs: human umbilical cord-mesenchymal stem cells; AD-MSCs: adipose tissue-derived mesenchymal stem cells; mESCs: mouse embryonic stem cells; AFSCs: amniotic fluid stem cells; USCs: urine-derived stem cells; Scr: serum creatinine; BUN: blood urea nitrogen; UAE: urinary albumin excretion; Ccr: creatinine clearance rate; MDA: malondialdehyde; GSH: L-glutathione; SOD: superoxide dismutase.