Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants

Table 2

Meta-analysis of the efficacy of MSC in therapy of renal injury induced by toxicant.

Indicators	Time point	Studies	test	Model	OR/WMD
		number	value	selected	(95% CI)
Scr	2 days	3	0.001	Random	-0.88 (-1.34, -0.42)	0.0002
	3 days	4	0.0004	Random	-0.09 (-0.25, 0.06)	0.24
	4 days	6	0.0002	Random	-0.74 (-0.95, -0.54)	<0.00001
	5 days	6	<0.00001	Random	-0.46 (-0.67, -0.25)	<0.0001
	6-8 days	7	<0.00001	Random	-0.55 (-0.84, -0.26)	0.0002
	10-15 days	11	<0.00001	Random	-0.37 (-0.53, -0.20)	<0.0001
	28-30 days	7	<0.00001	Random	-0.53 (-1.04, -0.02)	0.04
	≥42 days	6	<0.00001	Random	-0.22 (-0.39, -0.06)	0.007
BUN	2-3 days	6	<0.00001	Random	-25.08 (-37.49, -12.67)	<0.0001
	4-5 days	8	<0.00001	Random	-45.71 (-59.36, -32.05)	<0.00001
	6-8 days	5	<0.00001	Random	-57.55 (-99.19, -15.91)	0.007
	13-15 days	4	<0.00001	Random	-13.40 (-32.34, 5.54)	0.17
	≥28 days	8	<0.00001	Random	-23.39 (-36.39, -10.40)	0.0004
UAE	—	3	0.72	Fixed	-22.66 (-26.41, -18.90)	<0.00001
MDA	—	4	0.41	Fixed	-17.21 (-20.38, -14.04)	<0.00001
GSH	—	4	<0.00001	Random	4.62 (2.74, 6.50)	<0.00001
SOD	—	3	<0.00001	Random	5.42 (2.92, 7.93)	<0.0001
Renal pathology
Inflammatory cells	—	4	<0.00001	Random	-2.66 (-3.83, -1.49)	<0.00001
Necrotic tubule	—	2	<0.00001	Random	-2.58 (-4.75, -0.40)	0.02
Regenerative tubules	—	2	—	Fixed	6.00 (3.45, 8.55)	<0.00001
Renal interstitial fibrosis	—	3	<0.00001	Random	-5.82 (-7.41, -4.23)	<0.00001

Note: Scr: serum creatinine; BUN: blood urea nitrogen; UAE: urinary albumin excretion; Ccr: creatinine clearance rate; MDA: malondialdehyde; GSH: L-glutathione; SOD: superoxide dismutase.