Clinical Efficacy and Safety of Stem Cell-Based Therapy in Treating Asherman Syndrome: A System Review and Meta-Analysis

Table 1

Basic characters and primary treatment attempt for AS syndrome.

Authors	Country	Year	Number of patients	Age	Etiology	Symptoms	Prior repair attempts	Prior repair outcomes	IUA grade/score
Singh et al.	India	2014	6		D&C, genital TB	Infertility, amenorrhea	Hysteroscopic adhesiolysis + HT (ALL)	Failed	IUA grade III-IV
Santamaria et al.	Spain	2016	11		Hysteroscopic myomectomy,; D&C, unexplained	Scant spotting,; Amenorrhea	Reparative operative hysteroscopies + HT (8)	Failed	IUA grade I-III
Tan et al.	China	2016	7		Curettages	Infertility	Adhesiolysis + IUD + HT (5)	Failed	IUA grade III-V
Zhao et al.	China	2016	5		D&C	Infertility, Hypomenorrhea	Hysteroscopy adhesiolysis (all)	Failed	NA
Cao et al.	China	2018	26		D&C	Infertility, Hypomenorrhea, amenorrhea	Hysteroscopy adhesiolysis (all)	Failed	IUA score 9.12 ± 1.51
Lee et al.	Korea	2019	5		D&C, diagnostic laparoscopy, unexplained	Infertility	Hysteroscopy adhesiolysis + HT (all)	Failed	IUA grade III
Singh et al.	India	2020	12		D&C, Cesarean section, genital TB, postpartum sepsis	Amenorrhea,; Scanty spotting	Hysteroscopic adhesiolysis + HT (all)	Failed	IUA grade I-IV
Ma et al.	China	2020	12		Curettage, infection, unexplained	Refractory IUA, infertility	Hysteroscopic adhesiolysis + HT (all)	Failed	IUA grade III-IV

AS: Asherman syndrome; D&C: dilation and curettage; TB: tuberculosis; HT: hormone therapy; IUD: intrauterine device; IUA: intrauterine adhesion; NA: not applicable.