Clinical Efficacy and Safety of Stem Cell-Based Therapy in Treating Asherman Syndrome: A System Review and Meta-Analysis

Table 2

Characters of stem cell-based therapy in treating AS syndrome.

Authors/year	Cell source	Transplant cell type	Cell number (10^6)	Transplanted section	HT	Follow up (months)
Singh et al. 2014	Bone marrow	Mononuclear stem cells		Subendometrial transmyometrium injection; (fundus, anterior, posterior)	Oral estradiol valerate, 6 mg/day (12 weeks). Medroxy progesterone (last 10 days).; Patients (started menstruation): Shifted to cyclical oral estrogen valerate 2 mg (tid, day 1 to day 26), progesterone 10 mg daily (day 16 to day 25).	9
Santamaria et al. 2016	Per blood mobilization	CD133^+ bone marrow; Derived stem cells	123.6	Infusion into spiral arterioles	Hormonal replacement therapy (Progyluton™)	6
Tan et al. 2016	Menstrual blood	Menstrual blood; Derived stromal cells	10^6 (5 patients),; (2 patients)	Instill into uterus fundus	MenSCs collection (day 5), oestradiol (4 mg, 14 day). MenSCs transplant, oestradiol (6 mg, 21 day).; : progesterone injection 40 mg.	6
Zhao et al. 2016	Bone marrow	BM-mononuclear stem cells loaded in collagen scaffold	scaffold; ( cm^2)	Attach to the uterine wall	Progynova (6 mg, 10 days), operation, continuous Progynova (6 mg, 30 days), progesterone injection (60 mg, 30^th day)	3
Cao et al. 2018	Umbilical cord	Umbilical cord-derived; Mesenchymal stromal cells	10	Attach to the uterine wall	Progynova (6 mg, 10 days), operation, continuous Progynova (6 mg, 30 days), progesterone injection (60 mg, 30^th day)	30
Lee et al. 2019	Adipose tissue	Adipose-derived MSCs loaded in stromal vascular fraction	4.6	Cervical instillation	Oral estradiol valerate (6 mg, day1 to day 25),; Oral Medroxyprogesterone; (10 mg, day 21 to day 25)	23
Singh et al. 2020	Bone marrow	BM-mononuclear stem cells		Subendometrial transmyometrium injection; (fundus, anterior, posterior)	Oral estradiol valerate (2 mg, Tid,12 weeks), : Medroxyprogesterone; (10 mg, last 10 days in 12 week); : additional cycle.	60
Ma et al. 2020	Menstrual blood	Menstrual blood stem; Cells (MenSCs)	10	Endometrium	Oral estradiol (2 mg, Tid, 14 days); + additional 3 days()	NA

AS: Asherman syndrome; G-CSF: granulocyte colony-stimulating factor; BM: bone marrow; Tid: three times daily; ET: endometrium thickness.