Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and Osteoporosis
Table 1
DNA methylation in MSC aging and related diseases.
Regulatory factors
Mechanism
In vivo or in vitro
Consequence
Materials
Ref.
Senescence and aging
DNMT1↓ DNMT3b↓
Decreases methylation in the promoter region of miRNA targeting Ezh2 to decrease Ezh2 expression, thus inhibiting repressive H3K27me3 formation at p16’s promoter; directly decreases methylation in CDK inhibitor genes p16 and p21
The depletion of TET causes impeded demethylation of P2rX7 promoter and incapable exosome release, which leads to intracellular accumulated miR-297 targeting Runx2 signaling pathway