Quantification and Comprehensive Analysis of Mesenchymal Stromal Cells in Bone Marrow Samples from Sickle Cell Disease Patients with Osteonecrosis

Figure 3

Quantification of hematopoietic progenitors in BM-MNC and correlation of MSC with donor age. (a) Counting of CD45^dimCD34⁺ cells in BM-MNC. (b) Correlation between putative MSC (either CFU-F frequency or CD271⁺CD45^-/low cell counts) and increasing donor age. A Spearman test was used for the correlation analysis independent of osteoarticular complication. Black and dashed lines across data sets indicate of best fit for each group. Statistical analyses (Mann–Whitney test) were performed between values, and the data are reported as the median and interquartile range.

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