Stem Cells International / 2020 / Article / Fig 8

Research Article

Susceptibility to Ventricular Arrhythmias Resulting from Mutations in FKBP1B, PXDNL, and SCN9A Evaluated in hiPSC Cardiomyocytes

Figure 8

(a) Representative recordings from a WT and R391Q mutant in PXDNL cotransfected with SCN5A. I–V relation for WT and R391Q mutant in PXDNL cotransfected with SCN5A. The I-V relation was generated using same voltage clamp protocol described in Figure 5. A small reduction in density was noted with R391Q mutation. Representative recordings from a WT and R391Q (a) mutant in PXDNL cotransfected with KCND3. Current recordings were obtained at test potentials between −60 and 50 mV from a holding potential was −80 mV. (c) I–V relation for WT and R391Q showing a significant difference in Ito magnitude at potentials above -20 mV.
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