Metabolic Syndrome Alters the Cargo of Mitochondria-Related microRNAs in Swine Mesenchymal Stem Cell-Derived Extracellular Vesicles, Impairing Their Capacity to Repair the Stenotic Kidney

<div>miRNAs dysregulated in MetS-EVs are capable of targeting mitochondria-related genes. Predicted mitochondria target genes of differentially expressed miRNAs were identified (MitoCarta2.0) and classified by their cellular component (a), molecular function (b), and biological process (c). miRNAs dysregulated in MetS-EVs are capable of targeting several genes implicated in mitochondrial energy pathways, including the electron transport chain complexes I, II, III, IV, and V and the tricarboxylic acid (TCA) cycle.</div>

Stem Cells International

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Figure 3: Metabolic Syndrome Alters the Cargo of Mitochondria-Related microRNAs in Swine Mesenchymal Stem Cell-Derived Extracellular Vesicles, Impairing Their Capacity to Repair the Stenotic Kidney 

Figure 3 | Metabolic Syndrome Alters the Cargo of Mitochondria-Related microRNAs in Swine Mesenchymal Stem Cell-Derived Extracellular Vesicles, Impairing Their Capacity to Repair the Stenotic Kidney 