Metabolic Syndrome Alters the Cargo of Mitochondria-Related microRNAs in Swine Mesenchymal Stem Cell-Derived Extracellular Vesicles, Impairing Their Capacity to Repair the Stenotic Kidney

<div>MetS altered the expression of mitochondria-related genes and proteins of EVs. (a) Heat map of 43 mRNAs upregulated and 29 mRNAs downregulated in MetS-EVs versus Lean-EVs. (b) Heat map of 14 proteins upregulated and 10 proteins downregulated in MetS-EVs versus Lean-EVs. (c) Functional analysis of genes and proteins dysregulated in MetS-EVs revealed that they are implicated in important mitochondrial functions, such as organization, transport, and oxidation reduction processes.</div>

Stem Cells International

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Figure 4: Metabolic Syndrome Alters the Cargo of Mitochondria-Related microRNAs in Swine Mesenchymal Stem Cell-Derived Extracellular Vesicles, Impairing Their Capacity to Repair the Stenotic Kidney 

Figure 4 | Metabolic Syndrome Alters the Cargo of Mitochondria-Related microRNAs in Swine Mesenchymal Stem Cell-Derived Extracellular Vesicles, Impairing Their Capacity to Repair the Stenotic Kidney 